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KMID : 1059520090530020137
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Journal of the Korean Chemical Society
2009 Volume.53 No. 2 p.137 ~ p.143
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The Effect of Mobile Phase and Dissolving Solvent on the Enantiomer Separation Using a Covalently Immobilized Chiral Column Derived from Polysaccharide Derivative
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Huang Hu
Lee Beom-Gyu
Baek Chae-Sun
Lee Won-Jae
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Abstract
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Liquid chromatographic enantiomer separation of N-tert-butoxycarbonyl (BOC) α-amino acids and their ethyl esters was performed on covalently immobilized chiral column (Chiralpak IC) derived from polysaccharide derivative. The solvent versatility of the covalently immobilized Chiralpak IC in enantiomer separation of N-BOC α-amino acid ethyl ester derivatives was shown and the chromatographic parameters of their enantioselectivities and resolution factors were greatly influenced by the nature of the mobile phase. Also the effect on the dissolving solvent for these analytes on the enantiomer separation using the same mobile phase and the examples of preparative enantiomer separation on analytical column were shown.
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KEYWORD
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Enantiomer separation, Chiral column, Amino acid, Chiralpak IC, Liquid chromatography
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